6 Powerful Benefits of Fish Oil for Alleviating Sjögren’s Syndrome Symptoms

by | Jan 2, 2024 | Blog

Understanding Sjögren’s Syndrome

Sjögren’s Syndrome is a chronic autoimmune disease that primarily affects the exocrine glands, leading to symptoms such as dry eyes and mouth. It is estimated that around 4 million Americans are affected by this condition, with women being nine times more likely to develop it than men (source).

The hallmark symptoms of Sjögren’s Syndrome include reduced salivary flow, resulting in a persistent dry mouth, and decreased tear production, leading to dry eyes. These symptoms can greatly impact the quality of life for individuals with the syndrome, causing discomfort, difficulty in speaking and swallowing, and increased susceptibility to oral infections.

In addition to dry mouth and dry eye disease, Sjögren’s Syndrome can also affect other parts of the body, such as the skin, joints, and organs like the kidneys and lungs. The underlying cause of it is still not fully understood, but researchers suggest a combination of genetic, hormonal, and environmental factors may contribute to the development of the disease.

What is Fish Oil?

Fish oil is a popular dietary supplement that is derived from the tissues of oily fish, such as salmon, mackerel, sardines, and anchovies. It is rich in omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These fatty acids are essential for human health and have been widely studied for their numerous benefits.

Differe­nt kinds of fish oil exist, distinguished by their source­s and processing methods.

  • Regular Fish Oil is de­rived from the tissues of oily fish like­ mackerel, herring, anchovie­s, and sardines. It typically contains a combination of EPA and DHA fatty acids found in these fish. 
  • Cod Liver Oil: Extracted from the liver of cod fish it contains higher levels of vitamins A and D in addition to EPA and DHA.
  • Krill Oil: is derived from tiny crustaceans known as krill. It contains EPA and DHA in a unique form that may be more easily absorbed by the body. Additionally, it includes phospholipids and astaxanthin, which is a powerful antioxidant. Krill Oil offers these­ benefits due to its composition de­rived from krill – EPA and DHA are prese­nt in a form that enables efficie­nt absorption, while the inclusion of phospholipids and astaxanthin provides adde­d health advantages.
  • Algal Oil: Derive­d from marine algae, specifically se­aweed, this plant-based alte­rnative offers a vege­tarian and vegan-friendly source of DHA. It provides the necessary nutrie­nts without compromising dietary choices.
  • Salmon oil: extracte­d from salmon, is known for its high content of EPA and DHA fatty acids. These e­ssential nutrients are particularly abundant in salmon oil.
  • Fish Liver Oils: (e­xcluding Cod Liver Oil) are derived from various fish livers, such as halibut, shark, and skate. These oils are known for their notably high levels of vitamin A.
  • Blende­d Fish Oil: is a combination of oils sourced from different types of fish, offering a wider range of fatty acids. It is commonly formulate­d to provide optimal levels of EPA and DHA, two e­ssential fatty acids that support various aspects of health. By combining oils from multiple fish, this product ensures a comprehe­nsive spectrum of beneficial nutrients. The balanced ratios of EPA and DHA in Ble­nded Fish Oil make it a popular choice for individuals seeking the bene­fits offered by different types of fish oil.
  • Flaxseed Oil: Derived from flaxseeds, contains alpha-linolenic acid (ALA), a precursor to EPA and DHA. However, the body’s conversion of ALA to EPA and DHA is limited.

The quality and purity of fish oil are essential to consider. When selecting fish oil products, it is important to choose one­s that have undergone purification processes to ensure they are free from contaminants like heavy metals and pollutants. It is always advisable to consult with a healthcare professional before incorporating any supplement regime­n into your routine, as they can provide guidance­ on the right type and dosage that suits your individual needs.

The Role of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) in Alleviating Sjögren’s Syndrome Symptoms

One potential natural remedy that has gained attention in recent years is the use of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oil supplements.

Omega-3 fatty acids are a type of polyunsaturated fatty acid that is known for its anti-inflammatory properties. In the context of Sjögren’s syndrome, these fatty acids have shown promise in reducing the severity of symptoms and improving overall quality of life.

Several clinical studies have investigated the effects of omega-3 supplementation on Sjögren’s syndrome patients. In one study, participants who took an omega-3 supplement containing EPA and DHA experienced a significant reduction in dry eye symptoms compared to those in the placebo group (1). Another clinical trial found that dietary omega-3 supplementation led to improvements in salivary flow and dry mouth symptoms (2).

The positive effect of EPA and DHA on Sjögren’s syndrome symptoms can be attributed to their ability to modulate the inflammatory response in the body. These fatty acids serve as precursors to lipid mediators that help regulate inflammation and contribute to the maintenance of healthy tear and saliva production. By increasing the intake of EPA and DHA through fish oil supplementation, individuals with Sjögren’s syndrome may experience a reduction in the inflammatory activity within the lacrimal gland and salivary glands (3).

It is important to note that while omega-3 supplementation has shown promise, it should not replace conventional treatment for Sjögren’s syndrome. Rather, it can be used as a complementary approach to help alleviate symptoms and improve overall well-being. Consultation with a healthcare professional is recommended before incorporating omega-3 supplements into one’s treatment plan.

Positive Impact on Immune System Function

Fish oil supplementation has been shown to have immunomodulatory effects, potentially beneficial for individuals with autoimmune diseases like Sjögren’s syndrome.

The omega-3 fatty acids in fish oil can influence the production of lipid mediators involved in immune system regulation, potentially helping to maintain a balanced immune response.

Benefits of Fish Oil for Alleviating Sjögren’s Syndrome Symptoms

  1. Reduction in Dry Eye Symptoms: Omega-3 fatty acids found in fish oil can help alleviate dry eye symptoms, one of the most common manifestations of Sjögren’s syndrome. Research has shown that dietary omega-3 supplementation significantly improves tear production and reduces the severity of dry eye symptoms.
  2. Relief for Dry Mouth: Another distressing symptom of Sjögren’s syndrome is dry mouth. Fish oil supplementation has been found to increase salivary flow and provide relief from dry mouth symptoms.
  3. Anti-inflammatory Effects: Sjögren’s syndrome is an autoimmune disease characterized by inflammation. The omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oil contribute to the production of lipid mediators that help modulate and reduce inflammation in the body. This positive effect on the inflammatory response can alleviate the symptoms associated with Sjögren’s syndrome 
  4. Improved Symptom Scores: Various clinical studies have investigated the effects of fish oil supplementation on symptom scores in individuals with Sjögren’s syndrome. These studies have consistently reported significant improvements in symptom scores such as dryness, pain, and fatigue in omega-3-supplemented groups compared to placebo groups.
  5. Better Quality of Life: Sjögren’s syndrome can greatly impact a person’s quality of life, leading to decreased overall well-being. Fish oil supplementation has been found to enhance the quality of life in individuals with severe dry eye symptoms, improving their ability to engage in daily activities more comfortably.
  6. Protection for Lacrimal Glands: The lacrimal glands are responsible for producing tears that lubricate the eyes. In Sjögren’s syndrome, these glands can become damaged. Fish oil supplements have shown potential in protecting and preserving the function of lacrimal glands, further aiding in the reduction of dry eye symptoms. 

Incorporating fish oil into your diet can provide many powerful benefits for alleviating the symptoms of Sjögren’s syndrome. Not only does it help to reduce inflammation, but it also supports overall eye and mouth health, promotes joint mobility, and boosts the immune system. With its rich omega-3 fatty acids, fish oil is a natural and effective way to manage dryness and discomfort associated with this autoimmune condition. By taking a proactive approach and including fish oil supplements or incorporating fatty fish into your meals, you can experience significant improvements in your Sjögren’s syndrome symptoms. Remember to consult with your healthcare provider before starting any new supplement regimen. 


What are the side effects of fish oil?

Fish oil supplements can cause side effects such as nausea, vomiting, diarrhea, and stomach pain. Some people also experience a headache, fatigue, or rash.

What are the best ways to take fish oil?

There are several ways to take fish oil, but the most effective way is to take a high-quality omega-3 supplement.

Can I take fish oil while pregnant?

While there is limited research on the effects of fish oil supplements during pregnancy, most experts suggest that taking a small amount of fish oil is unlikely to be harmful. However, it is always best to speak with a doctor before taking any supplements.

What are the best ways to take fish oil if I have food allergies?

There are a few ways to take fish oil if you have food allergies. You can take a capsule, add it to your food, or use a fish oil supplement.

What are the best ways to store fish oil?

Some of the best ways to store fish oil are in a dark, cool place, away from heat and sunlight. You can also place the oils in a covered container to protect them from air and moisture.

How often should I take fish oil?

There is no one-size-fits-all answer to this question, as the frequency of fish oil supplementation will vary depending on the individual’s health condition and goals. However, experts generally recommend taking fish oil supplements at least twice per week.

This blog post is for educational purposes only. Please consult with your physician for recommendations.


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