Chronic Fatigue: Causes, Symptoms, Treatments and Effective Solutions

by | Jun 23, 2023 | Blog

Chronic Fatigue Defined

Chronic fatigue Syndrome (CFS) also known as Myalgic Encephalomyelitis (ME) refers to a persistent and debilitating condition characterized by extreme fatigue or tiredness that lasts for an extended time, typically six months or longer. It is not relieved by rest or sleep and significantly impacts daily functioning and quality of life. Individuals with chronic fatigue may experience a range of accompanying symptoms, including muscle aches, cognitive difficulties, impaired concentration, sore throat, joint pain, headaches, and unrefreshing sleep. The exact cause of chronic fatigue is unknown, and it can vary from person to person. It is a complex condition that often requires a comprehensive approach to management, involving medical evaluation, lifestyle adjustments, and support from healthcare professionals.

What else can it be besides chronic fatigue syndrome?

Diagnosing chronic fatigue can be challenging as several other medical conditions share similar symptoms. Some factors need to be ruled out before making a diagnosis of chronic fatigue. By eliminating other possible causes, we can provide an accurate diagnosis and appropriate treatment for individuals experiencing chronic fatigue.

  • Sleep Disorders

Before diagnosing someone with chronic fatigue, it is crucial to rule out other factors that can mimic its symptoms. By taking a comprehensive approach and considering these potential causes, healthcare professionals can provide appropriate treatment strategies tailored to the individual’s specific needs. Understanding the underlying factors behind chronic fatigue is essential for improving the quality of life for those living with this challenging condition

  • Thyroid Disorders

Thyroid disorders, such as hypothyroidism and hyperthyroidism, can often manifest as chronic fatigue. The thyroid gland is an essential component in maintaining the body’s metabolism and energy levels. When the thyroid gland produces an insufficient amount of hormones (hypothyroidism) or excessive amounts of hormones (hyperthyroidism), it can result in persistent fatigue. Blood tests to evaluate thyroid hormone levels can help rule out thyroid disorders as the cause of chronic fatigue.

  • Nutritional Deficiencies

Certain nutritional deficiencies can contribute to fatigue and mimic the symptoms of chronic fatigue syndrome. For instance, low levels of vitamin D, vitamin B12, iron, or magnesium can lead to persistent tiredness and weakness. Evaluating blood levels of these essential nutrients can help identify deficiencies and guide appropriate supplementation or dietary adjustments.

  • Mental Health Conditions

Mental health conditions like depression, anxiety, and chronic stress can often present with symptoms of chronic fatigue. Psychological factors can significantly impact energy levels and overall well-being. It is crucial to assess an individual’s mental health and rule out any underlying psychiatric conditions that may contribute to their fatigue. Collaboration between healthcare providers specializing in mental health and those focusing on chronic fatigue can aid in accurate diagnosis and comprehensive treatment planning.

  • Autoimmune Disorders

Several autoimmune disorders, such as fibromyalgia, lupus, and multiple sclerosis, can cause chronic fatigue. These conditions involve the immune system mistakenly attacking healthy tissues, leading to inflammation, pain, and fatigue. Comprehensive medical evaluations, including blood tests and imaging studies, are necessary to rule out autoimmune disorders that may be responsible for chronic fatigue symptoms.

  • Chronic Infections

Certain chronic infections, such as Epstein-Barr virus (EBV), Lyme disease, and hepatitis, can cause persistent fatigue. These infections can result in long-term consequences and impact energy levels. Through specialized testing and analysis of symptoms, healthcare providers can determine if chronic infections are contributing to the fatigue experienced by individuals.

Before diagnosing someone with chronic fatigue, it is crucial to rule out various other factors that can mimic its symptoms. By taking a comprehensive approach and considering these potential causes, healthcare professionals can provide appropriate treatment strategies tailored to the individual’s specific needs. Understanding the underlying factors behind chronic fatigue is essential for improving the quality of life for those living with this challenging condition.

Supplements and Herbs for Chronic Fatigue

When it comes to managing chronic fatigue, several supplements and herbs have been associated with potential benefits. However, it’s important to note that individual responses may vary, and it’s always advisable to consult with a healthcare professional before starting any new supplements. Here are some supplements and herbs that have been commonly used:

  • Coenzyme Q10 (CoQ10)

CoQ10 is a naturally occurring compound that plays a key role in cell energy production. Some studies suggest that CoQ10 supplementation may help improve energy levels and reduce fatigue in individuals with chronic fatigue syndrome.

  • Omega 3 Fatty Acids

Found in fish oil and certain plant sources, omega-3 fatty acids possess anti-inflammatory properties and support overall well-being. While research on omega-3 supplementation for chronic fatigue is limited, some studies indicate potential benefits in reducing fatigue and improving cognitive function.

  • Rhodiola Rosea

Rhodiola rosea is an adaptogenic herb known for its potential to enhance energy and reduce fatigue. In addition, it holds the potential to enhance mood and promote cognitive function. However, individual responses may vary, and it’s advisable to start with a low dosage and monitor for any adverse effects.

  • Ginseng

Ginseng is a popular herb that has been used in traditional medicine to combat fatigue and enhance vitality. It may help improve energy levels, mental clarity, and overall well-being. Different types of ginseng, such as Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius), have been studied for their potential benefits.

  • Ashwaganda

Ashwagandha, renowned for its adaptogenic properties, is a widely utilized herb in Ayurvedic medicine. It may help reduce stress, improve energy levels, and enhance overall resilience. Some preliminary studies suggest that ashwagandha supplementation may benefit individuals with chronic fatigue.

  • B Vitamins

B vitamins, including B12, B6, and folate, are essential for energy production and nervous system function. Some individuals with chronic fatigue may have deficiencies in these vitamins, and supplementation under medical guidance may help alleviate fatigue symptoms.

Keep in mind that these supplements and herbs have shown potential benefits for some individuals, it’s crucial to consult with a healthcare professional before incorporating them into your routine. They can provide personalized recommendations based on your specific needs and help monitor for any interactions or side effects. Additionally, adopting a healthy lifestyle, managing stress, getting adequate sleep, and maintaining a balanced diet can also contribute to managing chronic fatigue effectively.

Labs to get when working up chronic fatigue

Before diagnosing chronic fatigue, several laboratory tests should be obtained to rule out other potential underlying causes. These tests may include:

  • Complete Blood Count (CBC)

A CBC helps evaluate the overall health of blood cells, including red blood cells, white blood cells, and platelets. It can detect conditions such as anemia or infections that may contribute to fatigue.

  • Thyroid Function Tests

These tests measure thyroid hormone levels, including thyroid-stimulating hormone (TSH), free thyroxine (T4), and triiodothyronine (T3). Thyroid disorders can cause fatigue, and these tests help assess thyroid function.

  • Vitamin and Mineral Levels

Blood tests can determine levels of essential vitamins and minerals, such as vitamin D, vitamin B12, iron, and magnesium. Deficiencies in these nutrients can lead to fatigue, and supplementation may be recommended if deficiencies are identified.

  • Infectious Disease Screening

Tests for specific infections like Epstein-Barr virus (EBV), Lyme disease, or hepatitis may be performed to rule out chronic infections that can cause fatigue.

  • Autoimmune Markers

Certain autoimmune markers, such as antinuclear antibodies (ANA), rheumatoid factor (RF), or specific autoantibodies, may be assessed to detect autoimmune disorders associated with chronic fatigue.

  • Liver and Kidney Function Tests

Evaluating liver and kidney function is important to identify any dysfunction that may contribute to fatigue.

  • Sleep Studies

In cases where sleep disorders are suspected, polysomnography or other sleep studies can assess sleep quality, detect sleep apnea, or identify other sleep-related issues.

These are some of the common laboratory tests that healthcare professionals may consider before diagnosing chronic fatigue. It is crucial to individualize the diagnostic approach based on individual unique symptoms and medical history. Proper evaluation and identification of any underlying conditions are essential for accurate diagnosis and appropriate management of chronic fatigue.

Can environmental toxins contribute to chronic fatigue?

There is emerging evidence suggesting a potential connection between environmental toxins and chronic fatigue. While the exact mechanisms are still being investigated, exposure to certain environmental toxins has been associated with the development or exacerbation of chronic fatigue symptoms in some individuals. Various types of toxins, including heavy metals (such as mercury, lead, and arsenic), volatile organic compounds (VOCs), pesticides, and molds, have been implicated as potential triggers or contributors to chronic fatigue. These toxins can enter the body through different routes, such as inhalation, ingestion, or skin absorption.

Research suggests that environmental toxins may disrupt normal cellular function, impairing the body’s immune system, hormone regulation, and detoxification processes. This can lead to systemic inflammation, oxidative stress, and mitochondrial dysfunction, which are believed to play a role in the development of chronic fatigue. Furthermore, environmental toxins can also impact the central nervous system, affecting neurotransmitter balance and neuroinflammation, which may contribute to the manifestation of fatigue, cognitive impairments, and other symptoms associated with chronic fatigue syndrome.

It is important that individual responses to environmental toxins can vary widely, and not everyone exposed to toxins will develop chronic fatigue. Other factors, such as genetic predisposition, overall health status, and lifestyle factors, can influence susceptibility and the manifestation of symptoms. While more research is needed to fully understand the complex relationship between environmental toxins and chronic fatigue, it is advisable to minimize exposure to known toxins whenever possible. This may include measures like avoiding exposure to environmental pollutants, maintaining good indoor air quality, eating a nutritious diet, and adopting lifestyle practices that support detoxification and overall well-being.

If an individual suspects a connection between their chronic fatigue symptoms and environmental toxins, consulting with a healthcare professional experienced in environmental medicine or functional medicine can guide appropriate testing, evaluation, and potential treatment strategies.

Diets For Chronic Fatigue

When it comes to diet recommendations for individuals with chronic fatigue, there is no one-size-fits-all approach. However, adopting a balanced and nutritious diet can support overall health and potentially alleviate some symptoms associated with chronic fatigue. Here are some general dietary considerations:

  • Balanced Macronutrients

Achieving a well-rounded macronutrient balance is crucial for individuals with chronic fatigue. Prioritize meals that encompass a combination of carbohydrates, proteins, and healthy fats. Complex carbohydrates found in whole grains, fruits, and vegetables supply a steady stream of energy, promoting sustained vitality throughout the day.  Lean proteins, like poultry, fish, beans, and nuts, support muscle repair and function. Healthy fats from sources like avocados, nuts, seeds, and olive oil can help reduce inflammation and support brain health.

  • Antioxidant-Rich Foods

Include plenty of antioxidant-rich foods in your diet, such as berries, leafy greens, colorful fruits and vegetables, and spices like turmeric and ginger. Antioxidants help protect cells from damage caused by oxidative stress and inflammation.

  • Omega-3 Fatty Acids

Incorporate sources of omega-3 fatty acids, such as fatty fish (salmon, mackerel, sardines), flaxseeds, chia seeds, and walnuts. Omega-3 fatty acids have anti-inflammatory properties and support brain health.

  • Hydration

To effectively manage chronic fatigue, it is crucial to maintain proper hydration by consuming an ample amount of water throughout the day. By prioritizing regular intake of sufficient water, you can support optimal bodily functions and prevent dehydration, which can contribute to increased fatigue. Dehydration can contribute to feelings of fatigue and decreased cognitive function.

  • Limit Processed Foods and Sugar

Minimize the consumption of processed foods, sugary snacks, and beverages. These can lead to energy crashes and inflammation. Instead, prioritize whole, unprocessed foods whenever you can.

  • Individual Sensitivities

Pay attention to how your body responds to certain foods. Some individuals with chronic fatigue may have sensitivities or intolerances to specific foods, such as gluten, dairy, or certain additives. Keeping a food diary or working with a healthcare professional can help identify any potential triggers.

  • Regular Meals and Snacks

Aim for regular meals and snacks throughout the day to provide a steady source of energy. Avoid long periods without eating, as this can contribute to energy dips.

Consult with a Registered Dietitian for personalized dietary recommendations. Consider consulting with a registered dietitian who specializes in chronic fatigue or functional medicine. They can provide tailored advice based on your specific needs and help identify any nutritional deficiencies.

Remember, nutrition is just one aspect of managing chronic fatigue. It is essential to adopt a holistic approach that includes adequate rest, stress management, regular exercise (as tolerated), and working closely with healthcare professionals to address any underlying causes or contributing factors.

Lifestyle Changes That Can Help With Chronic Fatigue

Incorporating certain lifestyle changes can potentially alleviate symptoms of chronic fatigue. While individual responses may differ, here are some general lifestyle recommendations to consider:

  • Prioritize Restful Sleep: Make getting restful sleep a priority by establishing a regular sleep schedule and developing a calming bedtime routine that works for you. Aim for 7-9 hours of quality sleep each night and create a sleep-friendly environment that promotes restful sleep.
  • Manage Stress: Implement stress-management techniques such as deep breathing exercises, meditation, yoga, or engaging in activities that bring you joy and relaxation. Stress reduction can positively impact energy levels and overall well-being.
  • Balanced Exercise Routine: Engage in regular physical activity at an intensity and duration suitable for your current energy levels. Consult with a healthcare professional to develop an exercise plan that accommodates your abilities and avoids overexertion.
  • Pace Yourself: Practice energy conservation by prioritizing activities, setting realistic goals, and pacing yourself throughout the day. Listen to your body’s cues and take breaks when needed to prevent excessive fatigue.
  • Balanced Nutrition: Follow a balanced diet that includes whole, nutrient-dense foods. Ensure a diverse intake of fruits, vegetables, lean proteins, healthy fats, and whole grains. Additionally, maintain proper hydration by consuming an ample amount of water throughout the day. This combination will provide essential nutrients and keep you well-hydrated, supporting your overall health and energy levels.
  • Establish Boundaries: Learn to set boundaries and prioritize self-care. Communicate your needs to friends, family, and coworkers to ensure you have the necessary support and understanding.
  • Cognitive Strategies: Explore cognitive techniques such as mindfulness, positive affirmations, and cognitive-behavioral therapy (CBT) to help manage negative thoughts, improve mental well-being, and cope with the challenges of chronic fatigue.
  • Support Network: Seek support from friends, family, or support groups where you can connect with others facing similar challenges. Sharing experiences and receiving support can provide emotional comfort and valuable coping strategies.
  • Work-Life Balance: Evaluate and adjust your workload, if possible, to create a healthier work-life balance. Prioritize activities and commitments that are most important to you, and consider delegating or seeking assistance when needed.
  • Medical and Therapeutic Support: Consult with healthcare professionals experienced in treating chronic fatigue. They can provide personalized advice, recommend appropriate treatments, and address any underlying medical conditions contributing to fatigue.

Note that managing chronic fatigue requires a personalized approach, and it may take time to find the strategies that work best for you. Be patient, listen to your body, and work closely with healthcare professionals to develop a comprehensive management plan tailored to your specific needs.

The connection between the mitochondria and chronic fatigue

Mitochondrial dysfunction has been suggested as a potential factor in chronic fatigue, although the exact relationship is still being studied. Mitochondria are the powerhouses of our cells, responsible for generating energy. When mitochondrial function is compromised, it can affect various bodily processes, including energy production. To address mitochondrial dysfunction in the context of chronic fatigue, several strategies are being explored:

  • Nutritional Support: Certain nutrients and supplements, such as CoQ10, L-carnitine, alpha-lipoic acid, and B vitamins, are believed to support mitochondrial function. 
  • Exercise: Regular exercise, as tolerated and guided by a healthcare professional, may help improve mitochondrial function. Gradual and gentle aerobic exercise, strength training, and flexibility exercises can support overall fitness and potentially enhance mitochondrial efficiency.
  • Stress Reduction: Chronic stress can negatively impact mitochondrial health. Implement stress management techniques like meditation, deep breathing exercises, yoga, or mindfulness practices to mitigate the impact of stress on mitochondria.
  • Sleep Optimization: Prioritize restful sleep to support mitochondrial regeneration and energy restoration. Establish a consistent sleep routine and create a sleep-friendly environment to promote quality sleep.
  • Antioxidant-Rich Diet: Consume a diet rich in antioxidants, found in fruits, vegetables, and whole foods. Antioxidants help neutralize harmful free radicals that can damage mitochondria.
  • Avoidance of Toxins: Limit exposure to environmental toxins and pollutants, as they can contribute to mitochondrial dysfunction. Minimize exposure to cigarette smoke, heavy metals, pesticides, and other harmful substances.

It’s important to keep in one’s self that the efficacy of these strategies may vary depending on individual circumstances, and more research is needed to establish their effectiveness in treating mitochondrial dysfunction associated with chronic fatigue. 


“You are not alone in your battle against Chronic Fatigue. Take care of yourself, seek support, and listen to your body. Small steps forward matter. Find joy in the little things and hold onto hope for better days ahead. You are stronger than you realize, and your uniqueness will light the way to brighter tomorrow”.


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