Mycotoxin Illness: The Mystery Cases

by | Aug 25, 2023 | Blog

What is Mycotoxin Illness?

Mycotoxin illness refers to the condition caused by exposure to mycotoxins, which are toxic substances produced by certain types of fungi or molds. When these mycotoxins are inhaled, ingested, or come into contact with the skin, they can lead to various health problems. Mycotoxin illness can manifest as respiratory issues, allergic reactions, neurological symptoms, fatigue, headaches, and other systemic effects. It is important to identify and address the source of mold exposure to prevent further health complications.

Mycotoxin illness, also known as mold toxicity, occurs when individuals are exposed to high levels of mycotoxins produced by certain molds. These molds can grow in damp or water-damaged buildings, such as homes or workplaces. When people inhale or come into contact with mycotoxins through airborne particles, food, or skin exposure, it can lead to a range of health issues. 

What symptoms can Mycotoxin Illness cause?

Mycotoxin illness can cause a variety of symptoms. These symptoms can vary from person to person and depend on the level and duration of exposure to mycotoxins. Common symptoms of mycotoxin illness include respiratory issues like coughing, wheezing, and difficulty breathing. Fatigue, brain fog, difficulty concentrating, and memory problems are also common. Individuals may experience joint pain, muscle aches, and headaches. Gastrointestinal issues like nausea, diarrhea, and abdominal pain can occur. Other symptoms may include skin rashes, sensitivity to light and sound, and mood disturbances. It’s important to note that these symptoms can be similar to other health conditions, so it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.

Mycotoxin illness, also known as mycotoxicosis, refers to the toxic effects that can occur due to exposure to mycotoxins, which are toxic substances produced by certain molds. The specific symptoms and health effects of mycotoxin illness can vary depending on the type and concentration of mycotoxin, duration, and extent of exposure, individual susceptibility, and other factors. Here are some potential health effects associated with mycotoxin illness:

  • Respiratory Issues: Inhalation of mold spores or mycotoxin-contaminated particles can lead to respiratory symptoms such as coughing, wheezing, shortness of breath, and respiratory tract irritation.
  • Allergic Reactions: Some individuals may develop allergic responses to mycotoxins, resulting in symptoms like sneezing, nasal congestion, watery eyes, itching, or skin rashes.
  • Neurological Symptoms: Certain mycotoxins have been associated with neurological symptoms, including headaches, dizziness, difficulty concentrating, memory problems, confusion, and mood disorders.
  • Fatigue and Weakness: Chronic fatigue, generalized weakness, and persistent tiredness are reported by some individuals with mycotoxin illnesses.
  • Gastrointestinal Issues: Mycotoxin exposure can sometimes result in gastrointestinal symptoms such as nausea, vomiting, diarrhea, abdominal pain, and changes in appetite.
  • Immune System Suppression: Some mycotoxins have immunosuppressive effects, which can weaken the immune system and make individuals more susceptible to infections.
  • Skin Problems: Contact with mycotoxins or mold-contaminated surfaces can occasionally cause skin irritation, rashes, or dermatitis.

How do we test for mold in the home?

There are several methods to test for mold in your home. Here are some common approaches:

  • Visual Inspection: Begin by visually examining your home for any indications of mold development. Look for visible mold growth on walls, ceilings, floors, and other surfaces. Pay attention to areas with moisture issues, such as bathrooms, kitchens, basements, and areas affected by water leaks.
  • Mold Testing Kits: You can purchase mold testing kits from home improvement stores or online. These kits typically include swabs or adhesive strips to collect mold samples. Follow the instructions provided with the kit to collect samples from different areas of your home. Afterward, the samples are dispatched to a laboratory for analysis.
  • Professional Mold Testing: Hiring a professional mold inspector is another option. These experts have the knowledge and tools to conduct a thorough inspection of your home. They may use various techniques, including air sampling, surface sampling, and moisture testing, to identify the presence of mold and determine its type and concentration.
  • Air Quality Testing: Indoor air quality testing can help assess the overall air quality in your home, including the presence of mold spores. This testing involves collecting air samples from different rooms and analyzing them for mold spores and other airborne contaminants. Professional indoor air quality specialists can perform this type of testing.

Remember that testing for mold can provide valuable information, but it’s equally important to address any moisture or water issues in your home, as they contribute to mold growth. If you suspect a significant mold problem or are experiencing health issues related to mold exposure, consulting a professional mold remediation company or an environmental specialist is recommended.

How do we test for mycotoxin illness?

Testing for mycotoxin illness typically involves a combination of medical evaluation and laboratory testing. Here’s an overview of the process:

  • Medical Evaluation: The first step is to consult with a healthcare professional, such as a integrative medicine doctor or an environmental medicine specialist. They will review your symptoms, medical history, and potential exposure to mold or mycotoxins. Additionally, a comprehensive physical examination may be performed.
  • Symptom Assessment: The healthcare professional will assess the symptoms associated with mycotoxin illness. These can include respiratory issues, fatigue, cognitive problems, gastrointestinal disturbances, skin rashes, and more. The presence of multiple symptoms, along with a history of mold exposure, may raise suspicion of mycotoxin illness.
  • Laboratory Testing: Various laboratory tests can be used to assess mycotoxin levels and their impact on the body. These tests may include:
    • Urine Mycotoxin Testing: Urine samples are analyzed for the presence and levels of mycotoxins. This type of testing can help identify specific mycotoxins that may be affecting your health.
    • Blood Testing: Blood samples may be analyzed for specific antibodies or markers associated with mycotoxin exposure. These tests can provide information about the immune response to mycotoxins.
    • Comprehensive Blood Panels: General blood tests may be conducted to assess overall health and identify any abnormalities or imbalances that could be linked to mycotoxin exposure.
    • Other Tests: Additional tests, such as stool analysis, respiratory function tests, and imaging studies, may be recommended based on your symptoms and the healthcare professional’s assessment.

It’s important to note that mycotoxin testing can be complex, and the interpretation of results requires expertise. Therefore, it is crucial to consult with a qualified healthcare professional who specializes in mycotoxin illness or environmental medicine to guide you through the testing process and help interpret the results accurately.

What studies have shown a connection to autoimmune disease with Mycotoxins?

While there is some evidence suggesting a potential link between mycotoxin exposure and autoimmune diseases, further research is needed to establish a definitive connection. Several studies have explored this topic, but it’s important to note that the findings are still emerging and the mechanisms behind the association are not fully understood.

Some studies have observed an increased prevalence of autoimmune conditions, such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus, in individuals exposed to mycotoxins. For example, research has indicated that mycotoxins may trigger an immune response that contributes to the development or exacerbation of autoimmune diseases in susceptible individuals.

Additionally, certain mycotoxins, such as aflatoxins and ochratoxins, have been investigated for their potential to disrupt immune system function and promote autoimmune responses. These mycotoxins have been found to induce inflammation and alter immune cell activity, which could potentially contribute to autoimmune processes. It’s worth noting that the existing studies have limitations, including small sample sizes, varying methodologies, and the presence of confounding factors. Therefore, more comprehensive research is needed to establish a clear causal relationship between mycotoxin exposure and autoimmune diseases. If you suspect a connection between mycotoxins and autoimmune disease, it’s advisable to consult with a healthcare professional who specializes in environmental medicine or related fields. They can provide personalized guidance and help determine the most appropriate course of action based on your specific circumstances.

A study published in the journal Toxicology and Applied Pharmacology in 2011 investigated the effects of aflatoxin B1, a mycotoxin produced by certain molds, on the immune system. The study found that aflatoxin B1 exposure could induce an autoimmune response in mice, leading to the development of autoantibodies and immune system dysfunction.

Another study published in the journal Environmental Health Perspectives in 2013 examined the association between mycotoxin exposure and autoimmune markers in humans. The researchers found that individuals with higher levels of mycotoxin exposure had an increased likelihood of having specific autoantibodies associated with autoimmune diseases such as lupus and rheumatoid arthritis.

In a case study published in the Journal of Clinical & Cellular Immunology in 2015, researchers reported a case of systemic lupus erythematosus (SLE) in a patient who had a history of exposure to mycotoxins. The authors suggested a potential connection between mycotoxin exposure and the development of autoimmune diseases.

There is a growing body of research suggesting a potential link between mycotoxins and autoimmune diseases. Mycotoxins are toxic substances produced by certain types of fungi, commonly found in damp or water-damaged environments. These toxins have the potential to enter the body through breathing, swallowing, or contact with the skin.

While there isn’t an extensive amount of clinical research specifically examining the relationship between mycotoxins and autoimmune diseases, some studies and case reports have reported associations. For example, a study published in the journal Toxins in 2016 titled “Mycotoxins and Autoimmunity: Contemporary Aspects on Etiopathogenesis, Diagnosis and Treatment” discussed the potential role of mycotoxins in triggering or exacerbating autoimmune conditions.

Another study published in the journal Autoimmunity Reviews in 2018 titled “Mycotoxins and autoimmune diseases: Know risk, know responsibility” explored the potential mechanisms through which mycotoxins could contribute to autoimmunity.

It’s important to note that while these studies suggest a possible connection, more research is needed to establish a definitive causal relationship between mycotoxins and autoimmune diseases. Furthermore, individual susceptibility and other environmental factors may also play a role in the development of autoimmune conditions.

How do we treat mycotoxin illness? 

The treatment of mycotoxin illness involves a comprehensive approach aimed at addressing both the underlying cause (exposure to mycotoxins) and the associated symptoms. Here are some important elements of treatment:

  • Identification and avoidance of exposure: The first step is to identify and eliminate the source of mycotoxin exposure. This may involve assessing your living or working environment for mold growth and taking necessary measures to remediate it. It’s important to ensure proper ventilation, humidity control, and regular cleaning to prevent mold growth.
  • Medical management: A healthcare professional experienced in environmental medicine or functional medicine may develop a personalized treatment plan based on your symptoms and test results. This may involve addressing specific symptoms or conditions associated with mycotoxin illness, such as allergies, respiratory issues, or immune dysfunction.
  • Detoxification support: Supporting the body’s natural detoxification processes is crucial in managing mycotoxin illness. This may involve dietary modifications, nutritional supplementation, and lifestyle changes to enhance liver function and elimination pathways.
  • Symptom management: Depending on your specific symptoms, various therapies may be employed to provide relief. This can include medications for pain, inflammation, or respiratory symptoms, as well as complementary approaches like acupuncture, chiropractic care, or mind-body techniques to address pain, stress, and overall well-being.
  • Nutritional support: A nutrient-dense diet rich in antioxidants, vitamins, and minerals can support the immune system and aid in recovery. Your healthcare provider may recommend dietary modifications or specific supplements to optimize your nutritional status and support healing.
  • Psychological support: Dealing with the challenges of mycotoxin illness can be emotionally and mentally taxing. Seeking support from a therapist or counselor can help you cope with the psychological aspects of the condition and enhance your overall well-being.

It’s important to note that the treatment approach may vary for each individual, as the severity of mycotoxin illness and the specific symptoms can differ. Working closely with a knowledgeable healthcare professional is crucial to develop a tailored treatment plan that addresses your unique needs.

Is there a connection between mycotoxin illness and mast cell activation syndrome(MCAS)?

While there is ongoing research exploring the relationship between mycotoxin illness and mast cell activation syndrome (MCAS), the exact connection between the two is not yet fully understood. Mast cells are immune cells that play a role in allergic reactions and inflammation. MCAS is a condition where these cells become overly responsive, leading to a range of symptoms.

Some studies suggest that exposure to mycotoxins, which are toxins produced by certain types of molds, may trigger mast cell activation and contribute to the development or worsening of MCAS symptoms in susceptible individuals. The toxins released by molds can activate mast cells and trigger an immune response, leading to symptoms such as respiratory issues, skin rashes, gastrointestinal problems, and neurological symptoms.

However, it’s important to note that not everyone exposed to mycotoxins will develop MCAS, and not all individuals with MCAS have a history of mycotoxin exposure. Other factors, such as genetic predisposition, environmental triggers, and overall immune system health, can also influence the development and progression of MCAS.

Further research is needed to better understand the complex relationship between mycotoxin illness and MCAS. If you suspect you have MCAS or are concerned about mycotoxin exposure, it is recommended to consult with a healthcare professional experienced in these areas for proper evaluation, diagnosis, and treatment. They can provide appropriate guidance and individualized care based on your specific symptoms and medical history.

What can we do to prevent Mycotoxin Illness?

To help prevent mycotoxin illness, there are several steps you can take:

  • Maintain a clean and dry environment: Regularly clean and inspect your home for any signs of moisture or mold growth. Address any water leaks or damp areas promptly to prevent mold formation.
  • Proper ventilation: Ensure good ventilation in your home, particularly in areas prone to moisture such as bathrooms, kitchens, and basements. Utilize exhaust fans or open windows to enhance air circulation and decrease humidity.
  • Control indoor humidity levels: Maintain indoor humidity levels between 30-50% to discourage mold growth. You may want to consider utilizing dehumidifiers in areas where humidity levels are high.
  • Address water damage promptly: If you experience any water damage, such as from floods or plumbing issues, clean and dry the affected areas within 24-48 hours to prevent mold growth.
  • Use mold-resistant materials: When renovating or building, opt for mold-resistant materials, such as mold-resistant drywall or paints.
  • Regular cleaning: Clean and dust your home regularly to reduce the presence of mold spores and other allergens. Pay attention to areas prone to moisture, such as bathrooms and kitchens.
  • Proper ventilation in high-moisture areas: Use ventilation fans or open windows when cooking, showering, or using appliances that generate moisture to prevent excessive humidity buildup.
  • Monitor indoor plants: Indoor plants can sometimes harbor mold growth. Keep an eye on their condition and promptly remove any signs of mold or mildew.
  • Be cautious with food storage: Properly store food items to prevent mold growth. Ensure food containers are tightly sealed, discard expired items, and promptly clean up any spills or moldy food.
  • Regular HVAC maintenance: Maintain your heating, ventilation, and air conditioning (HVAC) system by regularly cleaning or changing filters and having it inspected to prevent mold growth.

While these preventive measures can help reduce the risk of mycotoxin illness, it’s important to note that some individuals may be more susceptible to mold-related health issues. If you suspect mold exposure or are experiencing symptoms associated with mycotoxin illness, consult with a healthcare professional for proper evaluation and guidance.



  1. MisterT

    What to do when I obviously have inflammation, and I went to the Rheumatologist, and after testing, she said there was nothing she could do for me. Referred to immunologist. Now, I still have out of control inflammation, and I am not getting help. Who can I get to control my inflammation while I go to other doctors with inflammation getting worse.


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