Supplements for Sjögren’s

by | Jul 1, 2024 | Blog, Health & Wellness, Sjögren's Syndrome

Living with Sjögren’s syndrome can be challenging due to symptoms like dry eyes, dry mouth, and fatigue. While there’s no cure for this autoimmune condition, many people find relief from their symptoms through a combination of medical treatments, lifestyle changes, and dietary supplements. In this blog post, we’ll delve into the world of supplements and explore how they can help manage Sjögren’s syndrome symptoms.

Understanding Sjögren’s Syndrome

Sjögren’s syndrome is an autoimmune disorder characterized by inflammation of the glands that produce moisture, leading to dryness in various parts of the body, including the eyes, mouth, and throat. It can also cause fatigue, joint pain, and other systemic symptoms. Managing Sjögren’s involves addressing both the symptoms and the underlying immune system dysfunction.

Omega-3 Fatty Acids

Omega-3 fatty acids, commonly found in fish oil supplements and certain foods like salmon, walnuts, and flaxseeds, have gained attention for their potential benefits in managing Sjogren’s syndrome (SS), an autoimmune condition primarily characterized by dry eyes and mouth.

Found in fish oil supplements, are known for their anti-inflammatory properties. Research suggests that omega-3s may help reduce inflammation in the body, which can alleviate symptoms like joint pain and inflammation of the eyes and mouth. 

Moreover, omega-3 fatty acids have broader systemic effects beyond just the eyes and mouth. They have been shown to modulate immune responses and reduce inflammation throughout the body, which may be beneficial for individuals with SS who experience systemic manifestations of the disease, such as joint pain, fatigue, and organ involvement.

Adding it to your daily routine may help manage Sjögren’s symptoms and support overall health.

Vitamin D

Many people with autoimmune conditions, including Sjögren’s syndrome, have low levels of vitamin D. Vitamin D plays a crucial role in immune function, and supplementation may help modulate the immune response and reduce inflammation. Additionally, it supports bone health, which is important for individuals with Sjögren’s who may be at risk of osteoporosis.

Adding this vitamin to your regimen may help relieve symptoms linked to SS, especially in certain groups like individuals with multiple health conditions. With limited studies on vitamin D’s impact on SS and its effects on multiple organs, more randomized controlled trials are needed to confirm its role in SS’s underlying mechanisms.

Primrose Oil

Evening primrose oil (EPO) is a popular natural remedy for managing symptoms of Sjögren’s syndrome. Rich in gamma-linolenic acid (GLA), an omega-6 fatty acid, EPO offers anti-inflammatory properties that may help ease inflammation in the body, including the glands responsible for producing saliva and tears. By regulating inflammation, EPO could potentially alleviate discomfort associated with dry eyes and mouth, common symptoms of Sjögren’s syndrome.

Moreover, it is believed to promote skin health and support immune function, which can be beneficial for individuals with autoimmune disorders like Sjögren’s syndrome. While scientific evidence on the direct effects of EPO for SS is limited, many people have reported positive outcomes from incorporating this supplement into their daily routine.


Turmeric’s potential benefits for Sjögren’s syndrome extend beyond its anti-inflammatory properties. Some studies suggest that curcumin, the active compound in turmeric, may also support the function of salivary glands and improve saliva production, which can help alleviate dry mouth symptoms commonly experienced by individuals with Sjögren’s syndrome.

Additionally, turmeric’s antioxidant properties may protect against oxidative stress, which is implicated in the progression of autoimmune diseases like Sjögren’s syndrome.


Pycnogenol, a natural plant extract derived from French maritime pine bark, has gained attention for its potential therapeutic effects on Sjögren’s syndrome. Research suggests that Pycnogenol possesses antioxidant and anti-inflammatory properties, which may help alleviate symptoms associated with SS, such as dry eyes and dry mouth.

Additionally, pycnogenol has been shown to support immune function and improve microcirculation, which could benefit individuals with autoimmune conditions.

N-acetylcysteine (NAC) 

N-acetylcysteine (NAC) is a supplement that has been studied for its potential benefits in managing symptoms associated with Sjögren’s syndrome. As an antioxidant, NAC helps to neutralize harmful free radicals in the body, which may contribute to inflammation and tissue damage in autoimmune conditions.

Additionally, NAC is known for its mucolytic properties, meaning it can help break down and thin mucus, potentially easing symptoms of dryness in the eyes and mouth commonly experienced by individuals with Sjögren’s syndrome. Some research suggests that NAC may also modulate the immune response, which could be beneficial in autoimmune disorders. 

Marshmallow Root

Derived from the Althaea officinalis plant, has been traditionally used for its potential therapeutic properties, particularly in addressing symptoms associated with Sjögren’s syndrome. Rich in mucilage, marshmallow root is known for its demulcent and soothing effects on mucous membranes throughout the body, including the mouth and throat. In individuals with SS, who often experience dryness of the eyes, mouth, and throat, marshmallow root may offer relief by providing a protective coating and promoting hydration of the mucous membranes.

Additionally, marshmallow root is believed to possess anti-inflammatory properties, which could help alleviate inflammation and irritation in affected tissues. While scientific evidence supporting the specific use of marshmallow root for Sjögren’s syndrome is limited, anecdotal reports and traditional use suggest its potential benefits in managing symptoms associated with the condition. 

Slippery elm

Slippery elm, a tree native to North America, has a long history of use in traditional medicine for various health conditions, including those associated with Sjögren’s syndrome. The inner bark of the slippery elm tree contains mucilage, a gel-like substance that becomes slippery when mixed with water. This mucilage has demulcent properties, meaning it can soothe and coat irritated tissues, such as the mouth, throat, and digestive tract.

In individuals with SS, who often experience dryness and inflammation of these mucous membranes, slippery elm may offer relief by providing a protective barrier and promoting hydration. Additionally, slippery elm is believed to have anti-inflammatory effects, which could help reduce swelling and discomfort in affected areas.


Often referred to as “good” or “friendly” bacteria, are live microorganisms that confer health benefits when consumed in adequate amounts. These beneficial bacteria play a crucial role in maintaining a balanced microbiome, the community of microorganisms living in the gut. 

Many individuals with SS experience gastrointestinal symptoms such as bloating, gas, and irregular bowel movements, which can affect nutrient uptake and overall well-being. 

The gut microbiome plays a significant role in immune function, and probiotic supplements can help support a healthy balance of gut bacteria. Some people with Sjögren’s syndrome experience gastrointestinal symptoms like bloating and diarrhea, and probiotics may help alleviate these issues. Additionally, probiotics may support overall immune function and reduce inflammation.

Vitamin B12

Fatigue is a common symptom of Sjögren’s syndrome, and low levels of vitamin B12 can contribute to feelings of tiredness and weakness. Supplementing with vitamin B12 may help boost energy levels and alleviate fatigue in some individuals. Vitamin B12 is also essential for nerve health and may help improve cognitive function.

Vitamin C

Also known as ascorbic acid, is a vital nutrient with antioxidant properties that play numerous roles in the body, including supporting immune function, collagen synthesis, and tissue repair. While research specifically examining the effects of vitamin C supplementation on Sjogren’s syndrome (SS) is limited, its potential benefits may be relevant to individuals with this autoimmune condition.

One of the hallmark features of SS is oxidative stress, which occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them with antioxidants. This oxidative imbalance can contribute to tissue damage and inflammation in the salivary and lacrimal glands, leading to dry mouth and dry eyes, the primary symptoms of SS.

As an antioxidant, it helps combat oxidative stress by scavenging free radicals and reducing inflammation. By neutralizing ROS and protecting cells from oxidative damage, vitamin C may help alleviate some of the symptoms associated with SS, such as dryness and inflammation in the eyes and mouth.

Before starting any new supplement regimen, it’s essential to consult with healthcare providers, including rheumatologists and nutritionists. They can assess your individual health needs, monitor for potential interactions with medications, and provide personalized recommendations based on your specific symptoms and health goals.


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